step three.3. Risk Activities

Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).

One another Bmi and you can lbs were synchronised having BMD, and you can BMC indications while the most powerful Pearson’s correlation coefficients have been receive anywhere between pounds and BMC in total hip and you will trochanter nations and you may the fresh new weakest of those was in fact ranging from Body mass index and you will femoral shoulder BMC. The fresh new correlations between age and you will BMD and you can BMC indications was negative (Desk 4).

Age-adjusted proportion away from BMD and BMC type said because of the Bmi and pounds try shown for the Dining table 5. Lbs tended to reveal greater variations in BMD and you will BMC shipment whatsoever the latest analyzed skeletal sites compared to Body mass index. It was mirrored of the steeper slope (?) of the respective linear regression traces. The best difference in BMD and you will BMC distribution looked at the trochanter BMC with lumbar BMC to possess lbs. Weight is a vital predictor from BMD and you will BMC variation within the more mature Iranian people.

cuatro. Discussion

In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men hitch with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.

The latest elements for which fatty tissue exerts positive effects towards the BMD condition commonly completely obvious. The putative system importance out-of fat having skeletal ethics most likely lives in the brand new part of a lot adipokines inside the limbs renovations owing to affect each other formation and you will resorption. Has just, bones could have been considered an enthusiastic hormonal organ impacting fat control and you may sugar homoeostasis from methods regarding bones-derived affairs for example osteocalcin and you may osteopontin [23, 34–36]. New putative crosstalk between lbs while the skeleton comprises an effective homoeostatic viewpoints system where adipokines and you may molecules released of the osteoblasts and you will osteoclasts represent the web link out of an active bone-adipose axis [34–36]. Carrying excess fat is also from the BMD from the conversion process off androgen in order to the hormone estrogen , which advances bones size both in visitors [38, 39] and you will preserves healthy plasma degrees of insulin and you can controlling affairs and insulin-such as increases grounds-step one, leptin, and you can adiponectin . Concurrently, obesity brings padding to the stylish if there is a slide . However, the fresh elements wherein a few of these events can be found continue to be not sure.